英语翻译Other ComX pheromones—such as ComX168 and ComXRO-C-2,produced by strains 168 and RO-C-2 of B.subtilis,respectively—are predicted to be modified by farnesyl groups,based on the mass of their modifications1,2.Given the role of ComQ in t

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英语翻译Other ComX pheromones—such as ComX168 and ComXRO-C-2,produced by strains 168 and RO-C-2 of B.subtilis,respectively—are predicted to be modified by farnesyl groups,based on the mass of their modifications1,2.Given the role of ComQ in t
英语翻译
Other ComX pheromones—such as ComX168 and ComXRO-C-2,produced by strains 168 and RO-C-2 of B.subtilis,respectively—are predicted to be modified by farnesyl groups,based on the mass of their modifications1,2.Given the role of ComQ in the isoprenylation of each ComX variant5,the structures of these pheromones may be similar to that described here.Early work on the farnesyl modification of the C-terminal cysteine in peptides was reported for the sex pheromones of basidiomycete yeasts7.This type of post-translational modification is now recognized as quite common and is important for peptide and protein function8.Because the modification of tryptophan markedly alters the hydrophobicity and conformation of the unmodified peptide precursor,the elucidation of the pheromone structure will permit investigations of pheromone interactions with the cognate ComP receptors9 and the determinants of specificity in these interactions.Although several secondary metabolites of isoprenylated tryptophan derivatives are known,the ring structure we determined for the isoprenyl-modified tryptophan residue in the ComX pheromone is a unique post-translational modification.

英语翻译Other ComX pheromones—such as ComX168 and ComXRO-C-2,produced by strains 168 and RO-C-2 of B.subtilis,respectively—are predicted to be modified by farnesyl groups,based on the mass of their modifications1,2.Given the role of ComQ in t
其他ComX信息素,如ComX168和ComXRO -架C - 2 ,菌株生产的168和反渗透,架C - 2枯草杆菌,分别,预计将进行修改法尼基群体的基础上,大规模的modifications1 ,2 .鉴于作用ComQ的异戊二烯化的每一个ComX variant5 ,结构的这些信息素可能会相似,这里描述.早期工作的法尼基修改C -末端半胱氨酸的多肽是报告的性信息素的担子菌yeasts7 .这种类型的翻译后修饰现在是公认的很常见,是重要的多肽和蛋白质function8 .由于修改色氨酸显着改变了疏水性和构未修改的多肽前体,阐明了信息素的结构将允许调查信息素的相互作用与同源比较receptors9和特殊性因素在这些相互作用.尽管一些次生代谢产物的isoprenylated色氨酸衍生物众所周知,环结构,我们确定了isoprenyl修饰的色氨酸残留在ComX信息素是一种独特的翻译后修饰.